January 1, 1995Thrombosis and Haemostasis

Endothelial Cell Function, Including Tissue Factor Expression, Under Flow Conditions

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Population

Vascular endothelium / endothelial cells

Design

Review

Authors

EGEríc F. GrabowskiMassachusetts General Hospital FLFrances P LamHarvard University

Discussion

Member takes

Implication

Highlights shear-dependent endothelial protection at vascular sites; leaves open targeted therapies for low-shear prothrombotic regions.

Structured PICO

Population

Vascular endothelium / endothelial cells

Intervention

Various flow conditions (moderate, high, and low shear stress, pulsatile flow, cyclic wall stress)

Outcome

Antithrombotic, prothrombotic, and fibrinolytic responsessurrogate

Fluid shear stress dynamically regulates endothelial cell function, with low shear stress at vessel branch points predisposing to localized thrombosis and atherosclerosis.

Cite This Study

Grabowski et al. (1995) studied this question.

synapsesocial.com/papers/6a8d26296193ac906088db28 https://doi.org/10.1055/s-0038-1642664

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Ask AI

Bookmark

Endothelial Cell Function, Including Tissue Factor Expression, Under Flow Conditions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelial Cell Function, Including Tissue Factor Expression, Under Flow Conditions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider