August 1, 1980The Journal of Infectious Diseases
Rheumatoid Factor in Acute Viral Infections: Interference with Determination of IgM, IgG, and IgA Antibodies in an Enzyme Immunoassay
Population
Patient sera with acute viral infections
Comparison
Addition of IgM rheumatoid factor from IgM-IgG… vs Addition of control IgM
Design
Preclinical
Authors
Discussion
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Member takes
Implication
RF may confound viral antibody EIAs; leaves open whether RF mitigation improves diagnostic accuracy in patients.
Structured PICO
P
Population
Patient sera with acute viral infections (rubella, influenza, cytomegalovirus, respiratory syncytial virus, parainfluenza, adenovirus, mumps, or herpes simplex virus)
I
Intervention
Addition of IgM rheumatoid factor (RF) from IgM-IgG cryoglobulin to patient sera
C
Comparator
Addition of control IgM
O
Outcome
Interference with determination of IgM, IgG, and IgA viral antibodies in solid-phase enzyme immunoassay (EIA)surrogate
IgM rheumatoid factor interferes with solid-phase enzyme immunoassays for viral antibodies, highlighting the need to eliminate RF interference in these tests.
Cite This Study
Salonen et al. (1980) studied this question.