The study identifies specific residues on the APC light chain that form the binding surface for its anticoagulant cofactor, protein S.
1: Provides mechanistic insight into the activated protein C anticoagulant pathway; extends structural.
Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants.Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.
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Fernández et al. (2017) studied this question.
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