Population
Normal plasma and protein S depleted plasma
Comparison
13 commercial APTT reagents vs Modified Xa one-stage clotting assay
Design
Preclinical
Authors
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APTT assays warrant caution for protein C-S defect detection due to reagent variability; leaves open validation of Xa-based methods.
The study questions the validity of APTT-based assays for identifying qualitative protein C abnormalities with defective interaction with protein S due to variable sensitivity of commercial reagents.
D’Angelo et al. (1989) studied this question.
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