Intravenous amphetamine use can induce acute myocardial infarction via coronary artery spasm, particularly in the presence of coronary plaques.
IV amphetamine may trigger spasm at plaques causing AMI; hypothesis-generating for causality in broader cohorts.
A 27-year-old man developed acute myocardial infarction after intravenous amphetamine use. A coronary angiogram showed plaques in the mid-portion of the left anterior descending artery which developed coronary artery spasm after administration of intracoronary ergonovine. The findings in this case suggest that these coronary artery plaques played a role in the endothelial dysfunction resulting from amphetamine use, and that induction of coronary arterial spasm was the likely mechanism of amphetamine-related acute myocardial infarction.
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Hung et al. (2003) studied this question.
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