Why the study?
Does chronic administration of methamphetamine induce cardiac muscle lesions in a rat model?
Population
60 5-week-old male Wistar Kyoto rats (n=30 treated, n=30 controls)
Comparison
Methamphetamine 1 mg/kg/day subcutaneously… vs Age- and sex-matched Wistar Kyoto control rats
Design
Preclinical
Follow-up
56 days
Authors
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Suggests methamphetamine may induce human cardiomyopathy; leaves open clinical translation from rat models.
Does chronic administration of methamphetamine induce cardiac muscle lesions in a rat model?
Chronic methamphetamine administration in rats induces progressive myocardial lesions and mitochondrial degeneration that resemble human methamphetamine-associated cardiomyopathy.
He et al. (1996) studied this question.
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