Rat brain capillary endothelial cells and astrocytes express PAR-1 and PAR-3 receptors, which mediate thrombin-induced calcium signaling that can be blocked by plasmin.
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Plasmin blocks thrombin-induced calcium signaling via PAR-1/3 in rat brain cells; hypothesis-generating for cerebrovascular regulation, needs in vivo confirmation.
Bartha et al. (2000) studied this question.
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