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April 1, 1996Circulation Research

Evidence for the Presence of a Proteinase-Activated Receptor Distinct From the Thrombin Receptor in Vascular Endothelial Cells

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Population

Porcine coronary artery strips, anesthetized rats, rat aortic rings, and human platelets

Comparison

Trypsin and PAR-2-derived peptide (SLIGRL) vs Thrombin and thrombin receptor-derived peptide

Design

Preclinical

Authors

JHJoyce HwaUniversity of VermontLGLorraine GhibaudiCardiovascular Institute of the SouthPWPatricia A.M. WilliamsConsejo Nacional de Investigaciones Científicas y Técnicas

Discussion

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Implication

Supports PAR-2-mediated vasorelaxation without pathogenic effects in animals; leaves open translation to human therapy.

Structured PICO

P
Population
Porcine coronary artery strips, anesthetized rats, rat aortic rings, and human platelets
I
Intervention
Trypsin and PAR-2-derived peptide (SLIGRL)
C
Comparator
Thrombin and thrombin receptor-derived peptide (SFLLRN)
O
Outcome
Endothelium-dependent relaxations and hemodynamic responsessurrogate

PAR-2 is present on vascular endothelial cells and mediates vasorelaxation without the pathogenic properties (platelet aggregation, smooth muscle contraction) associated with the thrombin receptor.

Cite This Study

Hwa et al. (1996) studied this question.

synapsesocial.com/papers/6a83ced3e84e9a3f81ee75ebhttps://doi.org/10.1161/01.res.78.4.581
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Vascular Reactivity After Acute Myocardial Ischemia1982 · 329 citations
  2. 2Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.1981 · 380 citations
  3. 3The Endothelium — Modulator of Vascular Smooth-Muscle Tone1988 · 297 citations
  4. 4A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells1991 · 89 citations