June 29, 1998Circulation Research

Atypical Protease-Activated Receptor Mediates Endothelium-Dependent Relaxation of Human Coronary Arteries

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Population

Human coronary artery ring segments suspended in organ chambers for isometric tension recording and…

Design

Preclinical

Authors

JHJustin R. HamiltonAustralian Centre for HIV and Hepatitis Virology Research PNPaul B. NguyenThe University of Melbourne TCThomas M. CocksBaker Heart and Diabetes Institute

Discussion

Member takes

Implication

Indicates PAR-1-like receptors mediate NO-dependent coronary relaxation; leaves open their role in human vasomotor control and therapeutic targeting.

Structured PICO

Population

Human coronary artery ring segments suspended in organ chambers for isometric tension recording and contracted with the thromboxane A2 mimetic U46619

Intervention

Thrombin (0.001 to 0.1 U/mL), trypsin (0.001 to 1 U/mL), and synthetic PAR-1 tethered ligand sequence SFLLRN-NH2 (0.01 to 10 micromol/L)

Outcome

Endothelium-dependent vascular relaxationsurrogate

Human coronary artery endothelial cells possess a PAR-1-like receptor that is potently activated by thrombin, trypsin, and SFLLRN-NH2 to cause NO-mediated vascular relaxation.

Cite This Study

Hamilton et al. (1998) studied this question.

synapsesocial.com/papers/6a83fbcb3fd01c19a6c58c9f https://doi.org/10.1161/01.res.82.12.1306

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Implication

Indicates PAR-1-like receptors mediate NO-dependent coronary relaxation; leaves open their role in human vasomotor control and therapeutic targeting.

Atypical Protease-Activated Receptor Mediates Endothelium-Dependent Relaxation of Human Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atypical Protease-Activated Receptor Mediates Endothelium-Dependent Relaxation of Human Coronary Arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider