July 6, 2001Circulation Research

Increased Expression of Protease-Activated Receptor-2 (PAR2) and PAR4 in Human Coronary Artery by Inflammatory Stimuli Unveils Endothelium-Dependent Relaxations to PAR2 and PAR4 Agonists

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Structured PICO

Population

Human isolated coronary arteries (HCAs)

Intervention

Exposure to inflammatory stimuli (interleukin (IL)-1alpha 1 ng/mL or tumor necrosis factor-alpha 3 nmol/L for 12 hours) followed by PAR2- or PAR4-activating peptides (SLIGKV and GYPGQV up to 100 micromol/L)

Comparator

Unexposed HCAs (baseline state)

Outcome

Endothelium-dependent relaxation and PAR1, PAR2, and PAR4 mRNA expression levelssurrogate

Inflammatory stimuli upregulate functional PAR2 and PAR4 receptors in human coronary arteries, enabling endothelium-dependent relaxation in response to their agonists.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May modulate coronary vasoreactivity in inflammation; leaves open PAR2/4 as therapeutic targets pending human validation.

Cite This Study

Hamilton et al. (2001) studied this question.

synapsesocial.com/papers/6a83ced0e84e9a3f81ee75e3 https://doi.org/10.1161/hh1301.092661

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Increased Expression of Protease-Activated Receptor-2 (PAR2) and PAR4 in Human Coronary Artery by Inflammatory Stimuli Unveils Endothelium-Dependent Relaxations to PAR2 and PAR4 Agonists

Structured PICO

Discussion

Implication

Cite This Study

Increased Expression of Protease-Activated Receptor-2 (PAR2) and PAR4 in Human Coronary Artery by Inflammatory Stimuli Unveils Endothelium-Dependent Relaxations to PAR2 and PAR4 Agonists

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider