July 1, 2001Journal of Cardiovascular Pharmacology

Protease-Activated Receptor (PAR) 1 but Not PAR2 or PAR4 Mediates Endothelium-Dependent Relaxation to Thrombin and Trypsin in Human Pulmonary Arteries

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Population

Isolated human pulmonary arteries

Design

Preclinical

Authors

JHJustin R. HamiltonAustralian Centre for HIV and Hepatitis Virology Research JMJames D. MoffattSt George's, University of London AFAlbert G. FraumanThe University of Melbourne

Discussion

Member takes

Implication

PAR1-selective modulation may influence vascular tone; leaves open PAR2/4 contributions in human disease or other beds.

Structured PICO

Population

Isolated human pulmonary arteries

Intervention

Thrombin (0.001-0.1 U/ml), trypsin (0.01-1 U/ml), and PAR-activating peptides (SFLLRN, SLIGKV, GYPGQV)

Outcome

Endothelium-dependent relaxationsurrogate

In human pulmonary arteries, only PAR1 (or a PAR1-like receptor) mediates endothelium-dependent relaxation to thrombin and trypsin, despite the expression of PAR2 and PAR4.

Cite This Study

Hamilton et al. (2001) studied this question.

synapsesocial.com/papers/6a83ced0e84e9a3f81ee75e4 https://doi.org/10.1097/00005344-200107000-00012

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