Population
Endothelium-denuded and intact human umbilical vein ring preparations, and endothelium-free rat aorta rings
Comparison
Proteinase-activated receptor-2-activating… vs Endothelium-denuded preparations and inactive…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open the unidentified EDCF's identity and role in human vascular tone.
PAR2-activating peptides induce endothelium-dependent contraction in human umbilical veins via a novel receptor and release of an unidentified endothelium-derived contracting factor.
Saifeddine et al. (1998) studied this question.
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