Population
Mice and a genetic cardiomyopathy hamster model
Comparison
Systemic delivery of AAVM41 vs Systemic delivery of AAV6 and AAV9 vectors
Design
Preclinical
Authors
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May advance cardiac gene therapy vectors; extends AAV engineering but leaves open human translation.
A novel AAV vector (AAVM41) developed via in vivo selection shows high myocardial tropism and successfully rescues cardiac function in a preclinical cardiomyopathy model.
Yang et al. (2009) studied this question.
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