Population
Single myocytes isolated from the endocardial surface of hypertrophied left ventricles of rats and normal…
Comparison
Exposure to phalloidin and/or cytochalasin D vs Normal left ventricular cells exposed to the…
Design
Preclinical
Follow-up
< 20 min
Authors
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Actin modulation of Ito1 in hypertrophied rat myocytes should not change practice; leaves open cytoskeletal roles in human ventricular remodeling.
The study demonstrates that hypertrophy-altered cytoskeletal actin microfilament regulation modifies transient outward potassium channel function in rat ventricular myocytes.
Yang et al. (2002) studied this question.
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