What question did this study set out to answer?

The research aims to identify the ionic mechanisms contributing to action potential lengthening in hypertrophied cardiac myocytes.

August 1, 1994Cardiovascular Research

Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages

Q: What is the clinical evidence from this study?

Study design: Other. Population: Cardiac hypertrophy and hypertension. Intervention: Hypertension and cardiac hypertrophy vs. Age-matched normotensive controls (WKY). Primary outcome: Action potential prolongation and ionic currents (Ito, ICa,L, Ilate, IK1).

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Key result

Cardiac hypertrophy in spontaneously hypertensive rats is associated with action potential prolongation due to specific reductions in the repolarizing transient outward potassium current (Ito).

Why the study?

Does cardiac hypertrophy in spontaneously hypertensive rats alter action potential duration and specific ionic currents compared to normotensive controls?

Population

Left ventricular myocytes isolated from spontaneously hypertensive rats and age-matched normotensive…

Comparison

Spontaneous hypertension and aging vs Age-matched normotensive Wistar Kyoto (WKY) rats

Design

Preclinical

Authors

ECElisabetta CerbaiElectrophysiology MBMario BarbieriUniversity of Bern QLQi LiChangchun University of Science and Technology

Discussion

Member takes

Implication

Ionic mechanisms in rat hypertrophy models; leaves open human translation and therapeutic targeting.

Key Points

The research aims to identify the ionic mechanisms contributing to action potential lengthening in hypertrophied cardiac myocytes.
Isolated left ventricular myocytes from spontaneously hypertensive rats (SHR) and normotensive controls (WKY) were analyzed.
Action potentials and ionic currents recorded using patch pipette techniques.
Comparison between myocardial cells of SHR at 3 months and 18 months of age with age-matched WKY.
Higher membrane capacitance noted in SHR myocytes compared to WKY.
Significant action potential prolongation in 18-month-old SHR compared to corresponding WKY and 3-month-old SHR.
Reduced Ito density in SHR myocytes versus WKY, especially in 18 months versus 3 months SHR.

Structured PICO

Does cardiac hypertrophy in spontaneously hypertensive rats alter action potential duration and specific ionic currents compared to normotensive controls?

Population

Left ventricular myocytes isolated from 3- and 18-month-old spontaneously hypertensive rats and age-matched normotensive Wistar Kyoto rats.

Exposure

Spontaneous hypertension and aging (3 and 18 months)

Comparator

Age-matched normotensive Wistar Kyoto (WKY) rats

Outcome

Action potential duration and ionic currents (ICa,L, Ito, Ilate, IK1)surrogate

Action potential prolongation in hypertrophied hearts of hypertensive rats is driven by reductions in the transient outward potassium current (Ito), which worsens with the duration of hypertension.

Cite This Study

Cerbai et al. (1994) studied Cardiac hypertrophy and hypertension. Hypertension and cardiac hypertrophy vs. Age-matched normotensive controls (WKY) was evaluated on Action potential prolongation and ionic currents (Ito, ICa,L, Ilate, IK1). Cardiac hypertrophy in spontaneously hypertensive rats is associated with action potential prolongation due to specific reductions in the repolarizing transient outward potassium current (Ito).

synapsesocial.com/papers/6a6c08dd109fb9aed02454e6 https://doi.org/10.1093/cvr/28.8.1180

Topics

Hypertension management

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Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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