Non-uniform electrophysiological properties and electrotonic interaction in hypertrophied rat myocardium.
Population
Rat model of myocardial hypertrophy induced by renal hypertension (HBP) and normal (SHAM) hearts
Comparison
Myocardial hypertrophy induced by renal… vs Normal (SHAM) hearts
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Nonuniform AP prolongation in hypertrophied myocardium may increase arrhythmia susceptibility; leaves open ionic mechanisms and human translation for further study.
Structured PICO
P
Population
Rat model of myocardial hypertrophy induced by renal hypertension (HBP) and normal (SHAM) hearts
I
Intervention
Myocardial hypertrophy induced by renal hypertension
C
Comparator
Normal (SHAM) hearts
O
Outcome
Transmembrane action potentials, spatial steady state voltage decrement, and effective input resistance (Rin)surrogate
Myocardial hypertrophy in rats leads to non-uniform action potential prolongation without significant alterations in electrotonic coupling between cells.
Cite This Study
Keung et al. (1981) studied this question.