Why the study?
Does a computational model of SHR ventricular myocytes simulate the electrophysiologic changes of hypertrophy and reduced extracellular K+?
Population
Computational model of adult spontaneously hypertensive rat (SHR) ventricular myocyte
Comparison
Simulation of hypertrophy effects and reduced… vs Normal rat ventricular myocyte model
Design
Preclinical
Authors
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Model validates SHR myocyte simulation of hypertrophy-related APD and calcium changes; leaves open translation to diuretic effects in human LVH.
Does a computational model of SHR ventricular myocytes simulate the electrophysiologic changes of hypertrophy and reduced extracellular K+?
A computational model of spontaneously hypertensive rat ventricular myocytes successfully simulated prolonged action potential duration and increased inotropy, providing mechanistic insights relevant to hypertensive patients with LVH undergoing diuretic treatment.
PADMALA et al. (2003) studied this question.
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