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August 25, 2026Cancer Survivorship Research & CareOpen Access

Survivorship guidelines in pediatric and adolescent radiation oncology: a systematic review

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Authors

KSKelly SkeltonRoyal Adelaide HospitalSJSophie JessopWomen's and Children's HospitalMAMorgan AtkinsonRoyal Adelaide Hospital

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Implication

Systematic review reveals gaps in organ-at-risk monitoring guidelines for young cancer survivors, highlighting the need for localized clinical frameworks.

Key Points

  • To synthesize and critically appraise national and international survivorship guidelines and care pathways for children and young adults treated with radiation therapy.
  • Searched MEDLINE, Embase, and CINAHL databases, with screening and data extraction conducted independently by two reviewers using Covidence.
  • Evaluated the methodological quality of included guidelines and pathways using the AGREE II checklist and JBI critical appraisal tools.
  • Of 626 identified articles, 14 high-quality records were included in the final analysis.
  • Guidelines commonly identified cardiotoxicity, neurocognitive impairment, endocrine dysfunction, and secondary malignancies, but provided limited structured guidance for managing radiation-exposed organs at risk.
  • All identified evidence-based guidelines originated internationally, with no Australian-specific equivalents identified.

Cite This Study

Skelton et al. (2026) studied this question.

synapsesocial.com/papers/6a8d49f7e8bd2413309bbde8https://doi.org/10.1080/28352610.2026.2721073
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