Key result
Propranolol reversed alpha-adrenergic blockade produced by phenoxybenzamine, phentolamine, and tolazoline, restoring a practically normal pressor response to noradrenaline.
Why the study?
Does propranolol influence alpha-adrenergic blockade in dogs and isolated rabbit aortic strips?
Does propranolol influence alpha-adrenergic blockade in dogs and isolated rabbit aortic strips?
Absolute Event Rate: 45% vs -18%
Propranolol may influence alpha-adrenergic receptors in addition to its beta-blocking effects in preclinical models.
Indicates possible alpha effects of propranolol beyond beta-blockade in animals; leaves open relevance to human adrenergic therapy.
Although propranolol is thought to be a specific blocker of the 3-adrenergic receptor (Black, Crowther, Shanks, Smith & Dornhorst, 1964) it is well known that other $3-blockers, like dichloroisoproterenol, have sympathomimetic effects (Moran & Perkins, 1958).There are several indications in the literature (Hull, Eltherington & Horita, 1960;Gulati, Gokhale & Udwadia, 1965; Gongalves & Osswald, 1965) that p-blocking agents such as propranolol can influence the interaction of an a-receptor and a-adrenergic
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OLIVARES et al. (1967) studied Alpha-adrenergic blockade (n=26). Propranolol vs. Alpha-adrenergic blockade without propranolol was evaluated on Mean blood pressure response to noradrenaline 1 µg/kg (% change). Propranolol reversed alpha-adrenergic blockade produced by phenoxybenzamine, phentolamine, and tolazoline, restoring a practically normal pressor response to noradrenaline.
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