Key result
Chronic administration of propranolol (30 mg/day for 1 to 7 weeks) did not modify the numbers or affinities of specific beta-adrenoceptor binding sites in rat hearts compared to controls.
Why the study?
Does chronic administration of propranolol modify the numbers or properties of cardiac beta-adrenoceptors in rats?
Does chronic administration of propranolol modify the numbers or properties of cardiac beta-adrenoceptors in rats?
Chronic administration of propranolol does not modify the number or affinity of beta-adrenoceptors in rat hearts, suggesting catecholamine deprivation does not regulate cardiac beta-receptors as it does in the brain.
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Does not support propranolol-induced beta-adrenoceptor changes in rat heart; leaves open tissue-specific regulation versus brain.
Baker et al. (1980) studied this question. (+/-)-propranolol vs. Control was evaluated on Numbers and affinities of specific binding sites for radioactive dihydroalprenolol in whole hearts. Chronic administration of propranolol (30 mg/day for 1 to 7 weeks) did not modify the numbers or affinities of specific beta-adrenoceptor binding sites in rat hearts compared to controls.
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