What does this research mean for the field?

Chronic administration of the beta-adrenoceptor antagonists tertatolol or propranolol induces hypersensitivity in cardiac responses without increasing beta-adrenoceptor density or adenylate cyclase levels, suggesting the mechanism involves enhanced receptor-G-protein coupling. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1995Journal of Autonomic Pharmacology

β‐Adrenoceptor regulation in rat heart, lung and skin after chronic treatment with (‐)‐tertatolol or (‐)‐propranolol

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Structured PICO

Population

Sprague-Dawley rats

Intervention

(-)-tertatolol (50 micrograms kg-1 hr-1) or (-)-propranolol (250 micrograms kg-1 hr-1) via subcutaneous osmotic minipumps for 14 days

Comparator

Vehicle (1 mM HCl) via subcutaneous osmotic minipumps for 14 days

Outcome

Beta-adrenoceptor populations in heart, lung, and skin, and atrial inotropic/chronotropic responsivenesssurrogate

Chronic beta-blocker administration in rats induces hypersensitivity of beta-adrenoceptor-mediated responses without increasing receptor density, likely through enhanced G-protein coupling.

Discussion

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Implication

Indicates post-receptor sensitization after chronic beta-blockade in rats; leaves open translation to clinical practice.

Cite This Study

Tan et al. (1995) studied this question.

synapsesocial.com/papers/6a1bcfaffc87fd06169cda63 https://doi.org/10.1111/j.1474-8673.1995.tb00407.x

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β‐Adrenoceptor regulation in rat heart, lung and skin after chronic treatment with (‐)‐tertatolol or (‐)‐propranolol

Structured PICO

Discussion

Implication

Cite This Study

β‐Adrenoceptor regulation in rat heart, lung and skin after chronic treatment with (‐)‐tertatolol or (‐)‐propranolol

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider