Key result
Chronic carteolol reduces cardiac β-adrenoceptors in hypertensive rats while propranolol increases them.
Why the study?
Does chronic administration of carteolol affect the number of cardiac β-adrenoceptors in spontaneously hypertensive rats compared to propranolol?
Does chronic administration of carteolol affect the number of cardiac β-adrenoceptors in spontaneously hypertensive rats compared to propranolol?
Carteolol, a β-blocker with intrinsic sympathomimetic activity, does not cause up-regulation of cardiac β-adrenoceptors in rats, suggesting a potential mechanism for the lack of rebound phenomena after discontinuation in humans.
No takes yet. Share an insight, caveat, or question.
May avoid β-adrenoceptor up-regulation in hypertensive rats unlike propranolol; leaves open relevance to human rebound risk.
Ebii et al. (1991) studied Hypertension (Spontaneously hypertensive rats). Carteolol vs. Propranolol (30 mg/kg) was evaluated on Number and affinities of cardiac β-adrenoceptors and heart rate. Chronic administration of 10 mg/kg carteolol significantly decreased the number of cardiac β-adrenoceptors in spontaneously hypertensive rats, whereas propranolol increased them.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: