Beta Blockers Induce Different Intrarenal Effects in Humans: Demonstration by Selective Infusion of Tertatolol and Propranolol

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Why the study?

Does selective infusion of tertatolol compared to propranolol induce different intrarenal vasomotor effects in patients with normal renal function?

Structured PICO

Does selective infusion of tertatolol compared to propranolol induce different intrarenal vasomotor effects in patients with normal renal function?

Population

8 patients with normal renal function

Intervention

Selective infusion of tertatolol (0.25 mg) into the left renal artery

Comparator

Selective infusion of propranolol (2.5 mg) into the left renal artery

Outcome

Left renal blood flow measured by continuous thermodilution method at 5, 10, 20, and 30 minutes post-infusionsurrogate

Selective infusion of tertatolol, but not propranolol, induces a delayed intrarenal vasodilator effect in humans with normal renal function.

No takes yet. Share an insight, caveat, or question.

Tertatolol may acutely increase renal blood flow unlike propranolol; leaves open clinical relevance in renal disease.

Nitenberg et al. (1990) studied this question.

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