Key result
Tertatolol increases glomerular filtration rate by ~9% vs propranolol in essential hypertension.
Why the study?
The renal hemodynamic effects of tertatolol compared to propranolol in essential hypertension were not well characterized.
Does tertatolol improve renal hemodynamics compared to propranolol in patients with essential hypertension?
Does tertatolol improve renal hemodynamics compared to propranolol in patients with essential hypertension?
Absolute Event Rate: 8.9% vs -2.8%
p-value: p=0.038
Tertatolol provides comparable antihypertensive efficacy to propranolol while improving rather than impairing renal perfusion in patients with essential hypertension.
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Suggests renal hemodynamic benefit with tertatolol; hypothesis-generating and requires prospective validation before practice consideration.
Paillard et al. (2008) studied essential hypertension. Tertatolol vs. Propranolol 160 mg slow release was evaluated on glomerular filtration rate (p=0.038). Tertatolol (5 mg) increased glomerular filtration rate (+8.9%; p=0.038) and renal plasma flow (+13.0%; p=0.007) in patients with essential hypertension, in contrast to propranolol.
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