Key result
Propranolol produced concentration-dependent relaxation of coronary arteries and dose-dependent falls in coronary perfusion pressure, likely through inhibition of calcium influx.
Why the study?
Does propranolol induce relaxation in isolated animal coronary arteries and hearts?
Does propranolol induce relaxation in isolated animal coronary arteries and hearts?
Propranolol may have relaxant activities on coronary arteries through inhibition of calcium influx in the cell membrane of coronary arterial smooth muscle.
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Should not change clinical practice; leaves open whether calcium influx inhibition extends to human coronary vasomotor effects.
Sakanashi et al. (1983) studied this question. dl-propranolol vs. lidocaine, atenolol, practolol was evaluated on Relaxation of coronary arterial strips and falls in coronary perfusion pressure. Propranolol produced concentration-dependent relaxation of coronary arteries and dose-dependent falls in coronary perfusion pressure, likely through inhibition of calcium influx.
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