Key result
Beta-thromboglobulin and platelet factor 4 were visualised in the alpha granules of human platelets and megakaryocytes, supporting their synthesis by parent megakaryocytes.
Beta-thromboglobulin and platelet factor 4 are localized in the alpha granules of human megakaryocytes and platelets, supporting their synthesis by parent megakaryocytes.
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Supports megakaryocyte origin of platelet proteins; leaves open validation in human disease models.
McLaren et al. (1982) studied this question. Immunological localisation techniques was evaluated on Localisation of beta-thromboglobulin and platelet factor 4. Beta-thromboglobulin and platelet factor 4 were visualised in the alpha granules of human platelets and megakaryocytes, supporting their synthesis by parent megakaryocytes.
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