Key result
VDJ rearrangement gene analysis confirmed that an isolated adrenal mass in a patient with prior nasopharyngeal lymphoma was a recurrence of the original neoplasm rather than a de novo tumor.
Case Report (n=1)
VDJ rearrangement gene analysis can be used to discriminate recurrence from metachronous NHLs in cases of isolated extranodal relapse.
May support VDJ analysis to distinguish recurrence from new lymphoma in isolated extranodal masses; leaves open prospective validation.
Diffuse large lymphomas of B-cell origin (DLBCL) comprise approximately one-third of all non-Hodgkin lymphomas (NHLs) and extranodal involvement is detected in 50% of these cases at initial diagnosis. Primary malignant lymphoma of the adrenal gland is extremely rare. Here we report a 64-year-old male patient with nasopharyngeal lymphoma who had been in remission for 2 years. An adrenal mass was detected on a control abdominal computed tomography (CT) at one of his follow-up visits. The biopsy showed DLBCL. Since the tumor was solitary without any other nodal involvement, a new/de novo primary tumor was considered. Metachronous NHLs develop between 3 months and 15 years after a primary NHLs and VDJ (variable, diversity, joining) rearrangement gene analysis of the tumor tissue is recommended to discriminate recurrence from a metachronous NHLs. VDJ rearrangement gene analysis was consistent with the recurrence of the original neoplasm.
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Çömez et al. (2015) conducted a case report in Diffuse large B-cell lymphoma (DLBCL) relapse (n=1). VDJ rearrangement gene analysis was evaluated on Discrimination of recurrence from metachronous NHL. VDJ rearrangement gene analysis confirmed that an isolated adrenal mass in a patient with prior nasopharyngeal lymphoma was a recurrence of the original neoplasm rather than a de novo tumor.
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