Key result
Endogenous melatonin has powerful effects on cardiovascular variables, and low blood concentrations are associated with coronary artery disease, arterial hypertension, and congestive cardiac failure.
Why the study?
The physiological role of endogenous melatonin and its circadian rhythm in the human cardiovascular system warranted review, given its multivariable cardiovascular effects and altered concentrations in disease.
This review highlights the physiological role of endogenous melatonin in regulating cardiovascular functions and its potential implications in diseases like CAD, hypertension, and heart failure.
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Hypothesis-generating for melatonin as a cardioprotective agent; leaves open the need for.
Melatonin (MLT) "N-acetyl-5-methoxytryptamine"; a pineal hormone; has a diurnal variation and may be necessary for the suprachiasmatic nucleus (SCN) and peripheral tissue's molecular circadian clocks to be synchronized, has powerful receptor-dependent and receptor-independent effects on a number of cardiovascular (CV) variables, including endothelial cells function, thrombus formation, blood pressure (BP), and heart rate (HR). MLT possesses antioxidative, anti-inflammatory, chronobiotic, and perhaps epigenetics regulatory characteristics. Low blood concentrations of MLT have been found in persons who have coronary artery disease (CAD), arterial hypertension (HT), and congestive cardiac failure. The physiological function of endogenous MLT and its circadian rhythm in the human CV system is reviewed in this article.
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Bushra Khairuddin Abdulqader (2023) conducted a review in Cardiovascular disease. Endogenous Melatonin was evaluated. Endogenous melatonin has powerful effects on cardiovascular variables, and low blood concentrations are associated with coronary artery disease, arterial hypertension, and congestive cardiac failure.
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