Key result
Melatonin reduces vasoconstrictors and increases nitric oxide activity in simulated hypertensive endothelial cells.
Why the study?
The involvement of diurnal rhythmicity as a pathogenic factor in hypertension and the role of melatonin in hypertension-related circadian rhythm alterations are not fully understood.
No takes yet. Share an insight, caveat, or question.
Does not support clinical use in hypertension; leaves open whether endothelial effects translate in vivo.
Shao et al. (2017) studied Hypertension (simulated). Melatonin was evaluated on Levels of vasoactive substances (ET, Ang II, NO, eNOS) and gene expression. Melatonin decreased endothelin and angiotensin II while elevating nitric oxide and eNOS activity in human umbilical vein endothelial cells under simulated hypertension.
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