July 1, 2003Circulation
Spatial Distribution of Phase Singularities in Ventricular Fibrillation
Key result
Phase singularities colocalizing at anatomic substrates had significantly longer life spans than nonanatomic phase singularities (82.46±60.8 vs 40.5±31.9 ms, P<0.01).
Population
Fibrillating ventricles (specific model not stated in abstract)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Anatomic substrates may stabilize VF phase singularities in animals; leaves open translation to human mechanisms or therapies.
Structured PICO
P
Population
Fibrillating ventricles (specific model not stated in abstract)
E
Exposure
Voltage, phase, and phase singularity (PS) mapping using an automated PS detection algorithm on optically recorded fibrillation signals
O
Outcome
Spatial distribution, behavior, and life spans of phase singularities (PSs)surrogate
Main Result
Absolute Event Rate: 82.46% vs 40.5%
p-value: p=<0.01
Phase singularities during ventricular fibrillation occur in nonrandom spatial distributions that colocalize with normal anatomic heterogeneities, which act as stabilizers and increase their life spans.
Cite This Study
Valderrábano et al. (2003) studied Ventricular Fibrillation. Anatomic substrates vs. Nonanatomic areas was evaluated on Phase singularity life span (p=<0.01). Phase singularities colocalizing at anatomic substrates had significantly longer life spans than nonanatomic phase singularities (82.46±60.8 vs 40.5±31.9 ms, P<0.01).