What question did this study set out to answer?

To evaluate the effect of the ACE inhibitor captopril on regional cerebral blood flow and assess whether it can preserve viable tissue in the peri-infarct zone during acute stroke.

November 1, 1989Journal of Cardiovascular Pharmacology

Angiotensin-Converting Enzyme Inhibition and Regional Cerebral Blood Flow in Acute Stroke

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Authors

GWGunhild WaldemarUniversity of Copenhagen SVS. VorstrupCopenhagen University Hospital AAAllan R. AndersenRigshospitalet

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Implication

Clinical study reveals captopril does not increase regional cerebral blood flow in acute stroke patients, suggesting ACE inhibition may not rescue peri-infarct brain tissue.

Key Points

To evaluate the effect of the ACE inhibitor captopril on regional cerebral blood flow and assess whether it can preserve viable tissue in the peri-infarct zone during acute stroke.
Assessed 12 patients within 5 days after their first acute stroke (N=12).
Measured regional cerebral blood flow via xenon-133 inhalation and SPECT scanning before and 1 hour after oral administration of 25 mg captopril.
Tracked changes in mean hemispheric blood flow, mean arterial blood pressure, and end-expiratory CO2 fraction.
No increase in regional cerebral blood flow occurred in any of the 12 patients following captopril administration.
Only one patient showed slight blood flow redistribution toward the ischemic low-flow area, with no increase in absolute flow.
Captopril produced no significant alterations in mean hemispheric blood flow, mean arterial blood pressure, or end-expiratory CO2 fraction.

Cite This Study

Waldemar et al. (1989) studied this question.

synapsesocial.com/papers/6a8d6f630bd5a3045f315361 https://doi.org/10.1097/00005344-198911000-00008

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Implication

Clinical study reveals captopril does not increase regional cerebral blood flow in acute stroke patients, suggesting ACE inhibition may not rescue peri-infarct brain tissue.

Angiotensin-Converting Enzyme Inhibition and Regional Cerebral Blood Flow in Acute Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Angiotensin-Converting Enzyme Inhibition and Regional Cerebral Blood Flow in Acute Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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