Key result
Captopril treatment increased cerebral blood flow to the affected hemisphere by 10%, compared to an 11% decrease with conventional therapy, suggesting it maintains autoregulation.
Why the study?
Does captopril improve cerebral blood flow in hypertensive patients with unilateral cerebrovascular disease compared to conventional therapy?
Population
19 hypertensive patients with unilateral cerebrovascular disease
Comparison
Captopril without or with a diuretic vs Conventional therapy
Design
Cohort
Authors
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Captopril may preserve cerebral autoregulation in hypertensive cerebrovascular disease; hypothesis-generating and should not yet change practice.
Cohort (n=19)
Does captopril improve cerebral blood flow in hypertensive patients with unilateral cerebrovascular disease compared to conventional therapy?
Absolute Event Rate: 10% vs -11%
Captopril appears to maintain cerebral autoregulation and improve blood flow to the affected hemisphere in hypertensive patients with cerebrovascular disease.
Britton et al. (1985) conducted a cohort in Hypertensive patients with cerebrovascular disease (n=19). Captopril (with or without a diuretic) vs. Conventional therapy was evaluated on Change in cerebral blood flow to the affected hemisphere (%). Captopril treatment increased cerebral blood flow to the affected hemisphere by 10%, compared to an 11% decrease with conventional therapy, suggesting it maintains autoregulation.
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