Key result
Immediate intensive insulin treatment reduced 1-year mortality by 30% in diabetic patients with acute myocardial infarction.
Why the study?
Does acute insulin-glucose infusion followed by multidose subcutaneous insulin reduce 1-year mortality in diabetic patients with acute myocardial infarction?
Population
620 diabetic patients with acute myocardial infarction
Comparison
Acute insulin-glucose infusion followed by… vs Control group (n=314)
Design
Cohort, prospective randomised study
Follow-up
1-year
Authors
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Should not yet change practice in diabetic AMI; leaves open need for randomized confirmation of mortality benefit.
RCT (n=620)
randomised
Does acute insulin-glucose infusion followed by multidose subcutaneous insulin reduce 1-year mortality in diabetic patients with acute myocardial infarction?
In diabetic patients with acute myocardial infarction, admission blood glucose is a strong predictor of mortality, highlighting the importance of good metabolic control over conventional risk factors.
K. Malmberg (1997) conducted an RCT in Acute myocardial infarction in patients with diabetes mellitus (n=620). Immediate intensive insulin treatment (acute insulin-glucose infusion followed by multidose subcutaneous insulin) vs. Controls was evaluated on 1-year mortality. Immediate intensive insulin treatment reduced 1-year mortality by 30% in diabetic patients with acute myocardial infarction.
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