Key result
Left bundle branch block in heart failure patients is associated with significantly lower pre-systolic kinetic energy of left ventricular Direct Flow compared to matched patients with normal conduction.
Why the study?
Does mechanical dyssynchrony (LBBB) alter left ventricular flow energetics in failing hearts compared to matched non-LBBB failing hearts?
Observational (n=22)
No
Does mechanical dyssynchrony (LBBB) alter left ventricular flow energetics in failing hearts compared to matched non-LBBB failing hearts?
p-value: p=0.018
4D flow CMR demonstrates that LBBB-related mechanical dyssynchrony reduces the pre-systolic kinetic energy of left ventricular direct flow, providing a potential novel marker for impaired diastolic function and CRT response.
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Suggests altered flow energetics may serve as a novel marker for impaired diastolic function.
Zajac et al. (2017) conducted an observational in Heart failure (n=22). Left bundle branch block (LBBB) vs. Matched heart failure patients without LBBB was evaluated on Kinetic energy (KE) of Direct Flow at end-diastole (ED) (p=0.018). Left bundle branch block in heart failure patients is associated with significantly lower pre-systolic kinetic energy of left ventricular Direct Flow compared to matched patients with normal conduction.
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