Cross-sectional echocardiographic assessment of the severity of aortic stenosis in children.
Key result
Cross-sectional echocardiography differentiated aortic stenosis severity, with the MACS/AOD ratio averaging 72.7% in normals, 53.1% in mild AS, and 29.9% in moderate/severe AS (P<0.001).
Why the study?
Does cross-sectional echocardiography accurately assess the severity of congenital valvular aortic stenosis in children?
Population
50 children, comprising 28 with congenital valvular aortic stenosis and 22 normal subjects.
Comparison
Real-time, cross-sectional echocardiographic… vs Normal subjects and varying degrees of aortic…
Design
Cross-sectional
Authors
Discussion
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Implication
May support non-invasive AS grading by MACS/AOD ratio in children; leaves open prospective validation against catheterization.
Study Design
Type
Cross-Sectional (n=50)
Structured PICO
Does cross-sectional echocardiography accurately assess the severity of congenital valvular aortic stenosis in children?
P
Population
50 children, comprising 28 with congenital valvular aortic stenosis and 22 normal subjects, evaluated using cross-sectional echocardiography.
E
Exposure
Real-time, cross-sectional echocardiographic assessment (measurement of maximum aortic cusp separation [MACS] expressed as a percentage of aortic root diameter [AOD]).
C
Comparator
Normal subjects and varying degrees of aortic stenosis severity (mild vs moderate/severe).
O
Outcome
Correlation of MACS/AOD ratio with peak systolic gradient and calculated aortic valve area.surrogate
Main Result
Absolute Event Rate: 53.1% vs 72.7%
p-value: p=<0.001
Cross-sectional echocardiography, specifically the MACS/AOD ratio, provides a reliable non-invasive method to estimate the severity of congenital aortic stenosis in children.
Cite This Study
Weyman et al. (1977) conducted a cross-sectional in Congenital valvular aortic stenosis (n=50). Cross-sectional echocardiography vs. Normal subjects was evaluated on Maximum aortic cusp separation (MACS) as a percentage of aortic root diameter (AOD) (p=<0.001). Cross-sectional echocardiography differentiated aortic stenosis severity, with the MACS/AOD ratio averaging 72.7% in normals, 53.1% in mild AS, and 29.9% in moderate/severe AS (P<0.001).