This guideline provides a standardized echocardiographic surveillance protocol to safely monitor LVEF and LVOT gradients in oHCM patients receiving mavacamten, operationalizing NICE safety requirements.
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Standardizes echocardiographic monitoring protocols essential for safe mavacamten initiation in obstructive hypertrophic cardiomyopathy;.
Hypertrophic cardiomyopathy (HCM) is a disease characterised by myocardial hypertrophy. This is linked to dysfunction of the cardiac sarcomere that results in excessive cardiac myosin–actin cross-bridging and increased sensitivity to calcium. Mavacamten is a selective, reversible myosin-inhibitor licensed in the United Kingdom as an oral therapy to treat symptomatic obstructive Hypertrophic Cardiomyopathy (oHCM) [ 1 , 2 ].
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Augustine et al. (2025) studied Obstructive hypertrophic cardiomyopathy. Mavacamten was evaluated. The British Society of Echocardiography outlines a standardized protocol for minimum standards of surveillance echocardiography in adult patients with obstructive hypertrophic cardiomyopathy receiving Mavacamten.
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