Key result
In heart failure patients with an ICD, chronic kidney disease was associated with a significantly worse event-free survival rate compared to its absence (51% vs. 76%, P<0.001).
Why the study?
Does the presence of comorbidities predict cardiac death and appropriate ICD therapy in patients with chronic heart failure and an ICD?
Population
146 patients with chronic heart failure, an implantable cardioverter-defibrillator, and systolic dysfunction
Comparison
Presence of comorbidities vs Absence of comorbidities
Design
Cohort
Follow-up
663 +/- 400 days
Authors
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CKD identifies higher-risk HF-ICD patients for closer monitoring; extends prognostic stratification but leaves open whether interventions improve survival.
Cohort (n=146)
Does the presence of comorbidities predict cardiac death and appropriate ICD therapy in patients with chronic heart failure and an ICD?
Absolute Event Rate: 51% vs 76%
p-value: p=< 0.001
In heart failure patients with an ICD, chronic kidney disease is an independent predictor of increased morbidity and mortality, including appropriate ICD therapy.
Bruch et al. (2007) conducted a cohort in Chronic heart failure with an ICD and systolic dysfunction (n=146). Chronic kidney disease vs. Absence of chronic kidney disease was evaluated on Cardiac death (p=< 0.001). In heart failure patients with an ICD, chronic kidney disease was associated with a significantly worse event-free survival rate compared to its absence (51% vs. 76%, P<0.001).
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