The prognosis of implantable defibrillator patients treated with cardiac resynchronization therapy: comorbidity burden as predictor of mortality
Key result
An age-adjusted Charlson comorbidity index score ≥ 5 was a significant predictor of mortality in heart failure patients receiving CRT-D (HR 3.69; 95% CI 2.06-6.60; P < 0.001).
Why the study?
Does a high comorbidity burden predict mortality in heart failure patients receiving CRT-D?
Population
463 heart failure patients who received a cardiac resynchronization therapy and defibrillation between 1999…
Design
Cohort
Follow-up
median 30.5 months
Authors
Discussion
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Member takes
Implication
CCI ≥5 may flag higher mortality risk in CRT-D recipients; leaves open whether comorbidity refines candidate selection.
Study Design
Type
Cohort (n=463)
Multicenter
Yes
Structured PICO
Does a high comorbidity burden predict mortality in heart failure patients receiving CRT-D?
P
Population
463 heart failure patients who received a CRT-D between 1999 and 2008, followed for a median of 30.5 months.
E
Exposure
Assessment of comorbidity burden using the Charlson comorbidity index (CCI)
O
Outcome
Mortality/survivalhard clinical
Main Result
Hazard Ratio: 3.69 (95% CI 2.06–6.6)
p-value: p=< 0.001
A high comorbidity burden, indicated by an age-adjusted CCI score ≥ 5, is a strong independent predictor of mortality in heart failure patients receiving CRT-D.
Cite This Study
Theuns et al. (2010) conducted a cohort in Heart failure (n=463). Age-adjusted Charlson comorbidity index score ≥ 5 vs. Lower comorbidity burden was evaluated on Mortality (HR 3.69, 95% CI 2.06-6.60, p=< 0.001). An age-adjusted Charlson comorbidity index score ≥ 5 was a significant predictor of mortality in heart failure patients receiving CRT-D (HR 3.69; 95% CI 2.06-6.60; P < 0.001).