Key result
Acute intravenous infusion of ascorbic acid increased carotid artery compliance by 26% in estrogen-deficient postmenopausal women (P<0.001), but had no effect in premenopausal women.
Why the study?
Does acute intravenous ascorbic acid improve carotid artery compliance in postmenopausal women?
Population
31 healthy sedentary women, comprising 10 premenopausal and 21 estrogen-deficient postmenopausal
Comparison
Acute intravenous infusion of supraphysiological… vs Acute intravenous infusion of saline
Design
Other
Follow-up
Acute
Authors
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May support testing antioxidants for postmenopausal arterial stiffness; hypothesis-generating and requires randomized confirmation.
Does acute intravenous ascorbic acid improve carotid artery compliance in postmenopausal women?
Effect estimate: 26% increase
Absolute Event Rate: 1.38% vs 1.11%
p-value: p=<0.001
Acute ascorbic acid infusion selectively improves large elastic artery compliance in estrogen-deficient postmenopausal women, suggesting oxidative stress contributes to arterial stiffening in this population.
Moreau et al. (2005) studied Healthy sedentary women (premenopausal and postmenopausal) (n=31). Ascorbic acid vs. Saline (baseline control) was evaluated on Carotid artery compliance in postmenopausal women (26% increase, p=<0.001). Acute intravenous infusion of ascorbic acid increased carotid artery compliance by 26% in estrogen-deficient postmenopausal women (P<0.001), but had no effect in premenopausal women.
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