Key result
In patients with acute STEMI, levels of F1+2 and d-dimer above the median were associated with an increased risk of the primary composite outcome (P=0.020 and P=0.010, respectively).
Why the study?
Are markers of thrombin generation (F1+2, d-dimer, ETP) measured in the acute phase of STEMI associated with long-term clinical outcomes?
Population
987 patients with ST-segment elevation myocardial infarction (STEMI)
Design
Cohort
Follow-up
median 4.6 years
Authors
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Acute-phase thrombin generation markers may help risk-stratify STEMI patients; leaves open whether.
Cohort (n=987)
Are markers of thrombin generation (F1+2, d-dimer, ETP) measured in the acute phase of STEMI associated with long-term clinical outcomes?
p-value: p=0.020 and 0.010
Markers of thrombin generation, specifically d-dimer and F1+2, measured in the acute phase of STEMI are associated with long-term adverse clinical outcomes.
Hansen et al. (2018) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=987). Prothrombin fragment 1+2 (F1+2), d-dimer, and endogenous thrombin potential (ETP) vs. Levels below median was evaluated on composite of all-cause mortality, reinfarction, stroke, unscheduled revascularization, or rehospitalization for heart failure (p=0.020 and 0.010). In patients with acute STEMI, levels of F1+2 and d-dimer above the median were associated with an increased risk of the primary composite outcome (P=0.020 and P=0.010, respectively).
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