Key result
Synthetic peptides XIP and C28R2 effectively inhibited SERCA and PMCA Ca2+ pumps, suggesting functional relatedness and common structural elements between their autoinhibitory domains.
Population
Sarcoplasmic reticulum (SERCA) and plasma membrane (PMCA) Ca2+ pumps (in vitro model)
Comparison
Synthetic peptides of the calmodulin-binding… vs Calmodulin-binding peptides from non-Ca2+…
Design
Preclinical
Authors
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Autoinhibitory peptide cross-inhibition of SERCA/PMCA suggests shared domains; leaves open in vivo validation and therapeutic relevance in cardiology.
Synthetic peptides from the autoinhibitory domains of Ca2+ transporters cross-react and inhibit both SERCA and PMCA pumps, suggesting shared structural elements.
Enyedi et al. (1993) studied this question. Synthetic peptides (XIP and C28R2) vs. Calmodulin-binding peptides from non-Ca2+ transport proteins was evaluated on Inhibition of SERCA and PMCA Ca2+ pumps. Synthetic peptides XIP and C28R2 effectively inhibited SERCA and PMCA Ca2+ pumps, suggesting functional relatedness and common structural elements between their autoinhibitory domains.
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