Key result
Korean red ginseng extract reduced cholesterol, LDL-C, and triglycerides, and normalized leptin, adiponectin, and insulin levels in mice fed a high-fat diet.
Why the study?
Does Korean red ginseng extract improve lipid metabolism and gene expression profiles in mice fed a high-fat diet?
Does Korean red ginseng extract improve lipid metabolism and gene expression profiles in mice fed a high-fat diet?
Korean red ginseng extract demonstrates anti-obesity and lipid-lowering effects in a high-fat diet mouse model by modulating hepatic gene expression and metabolic hormones.
May support preclinical lipid modulation; leaves open human translation and requires clinical trials before any practice consideration.
BACKGROUND: Ginseng saponin and ginsenosides exert anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti-obesity effects of ginseng and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti-obesity effects of Korean red ginseng extract (KRGE) and hepatic gene expression profiles in mice fed long-term on a high-fat diet (HFD) in this study. RESULTS: KRGE reduces the levels of cholesterol, low-density lipoprotein-cholesterol (LDL-C), serum triglycerides, and atherogenic indices. Levels of leptin, adiponectin and insulin, which regulate glucose and lipid metabolism, were impaired profoundly by HFD. However, KRGE treatment brought these levels back to normal. KRGE was found to down-regulate genes associated with lipid metabolism or cholesterol metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up-regulated by HFD. CONCLUSION: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing obesity.
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Song et al. (2011) studied High-fat diet-induced metabolic changes. Korean red ginseng extract (KRGE) vs. High-fat diet alone was evaluated on Lipid profiles and hepatic gene expression. Korean red ginseng extract reduced cholesterol, LDL-C, and triglycerides, and normalized leptin, adiponectin, and insulin levels in mice fed a high-fat diet.
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