Key result
Patients with accelerated, renovascular, or chronic renal disease hypertension were significantly less sensitive to infused angiotensin II and had higher renin activities compared to normal subjects (P <0.01).
Why the study?
Does sensitivity to infused angiotensin II correlate with plasma renin activity across different types of hypertension?
Observational (n=87)
Does sensitivity to infused angiotensin II correlate with plasma renin activity across different types of hypertension?
Sensitivity to infused angiotensin II inversely correlates with plasma renin activity, distinguishing secondary and accelerated forms of hypertension from essential hypertension and normal subjects.
Answers are grounded in this paper and cite their sources.
May refine subtyping of secondary hypertension; leaves open whether renin profiling improves outcomes.
For 67 patients, 66 with mild hypertension and one with Bartter's Syndrome, sensitivity to infused angiotensin II (expressed as critical dose) was significantly negatively correlated with renin activity in peripheral plasma (r = 0.698). Thirty-one patients with "benign" (essential) hypertension did not differ significantly from 20 normal subjects, with respect to circulating renin or angiotensin sensitivity; while 10 patients with accelerated hypertension, 10 with renovascular hypertension, and 14 with chronic renal disease and hypertension were less sensitive to angiotensin and had higher renin activities, with the deviations from normal in both parameters being statistically significant (P <0.01).
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Frank J. Catanzaro (1968) conducted an observational in Hypertension (n=87). Angiotensin II infusion test vs. Normal subjects was evaluated on Sensitivity to infused angiotensin II and renin activity in peripheral plasma (r = 0.698, p=<0.01). Patients with accelerated, renovascular, or chronic renal disease hypertension were significantly less sensitive to infused angiotensin II and had higher renin activities compared to normal subjects (P <0.01).
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