Key result
Sublingual captopril and nifedipine equally decreased mean arterial pressure to 94 mm Hg (P<0.001), but nifedipine significantly decreased PaO2 from 101 to 81 torr (P<0.01).
Why the study?
Does sublingual captopril compared to sublingual nifedipine improve hemodynamic and blood gas responses in patients with arterial hypertension after abdominal aortic surgery?
RCT (n=20)
randomized
No
Does sublingual captopril compared to sublingual nifedipine improve hemodynamic and blood gas responses in patients with arterial hypertension after abdominal aortic surgery?
Absolute Event Rate: 94% vs 94%
p-value: p=<.001
Sublingual captopril and nifedipine are equally effective for treating hypertension after abdominal aortic surgery, but captopril may be preferable as it does not impair pulmonary gas exchange.
Authors
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May prefer captopril over nifedipine for post-aortic surgery hypertension to preserve oxygenation; extends ACEI options in perioperative hypertension.
Leeman et al. (1995) conducted an RCT in Arterial hypertension after abdominal aortic surgery (n=20). Sublingual captopril vs. Sublingual nifedipine 10 mg was evaluated on Mean arterial pressure (p=<.001). Sublingual captopril and nifedipine equally decreased mean arterial pressure to 94 mm Hg (P<0.001), but nifedipine significantly decreased PaO2 from 101 to 81 torr (P<0.01).
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