Key result
Sublingual captopril lowers BP in ~90% of hypertensive emergencies, matching nifedipine in magnitude and duration.
Why the study?
Does sublingual captopril effectively and safely lower blood pressure compared to sublingual nifedipine in patients with hypertensive emergencies?
RCT (n=20)
Single-blind
randomized
Does sublingual captopril effectively and safely lower blood pressure compared to sublingual nifedipine in patients with hypertensive emergencies?
Absolute Event Rate: 90% vs 80%
Sublingual captopril is an effective and safe alternative to sublingual nifedipine for the immediate treatment of hypertensive emergencies.
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Supports sublingual captopril as safe alternative in hypertensive emergencies; extends options beyond nifedipine in this RCT.
P. Angeli (1991) conducted an RCT in hypertensive emergencies (n=20). Sublingual captopril vs. Sublingual nifedipine (10 mg) was evaluated on blood pressure lowering response. Sublingual captopril (25 mg) effectively lowered blood pressure in 90% of patients with hypertensive emergencies, with similar peak hypotensive magnitude and duration compared to sublingual nifedipine.
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