Key result
Sublingual captopril and nifedipine both produced a significant hypotensive effect at 5 minutes (P<0.001), but captopril caused no side-effects compared to 6 patients in the nifedipine group.
Why the study?
Does sublingual captopril reduce blood pressure with fewer side effects compared to sublingual nifedipine in patients with hypertensive emergencies?
Does sublingual captopril reduce blood pressure with fewer side effects compared to sublingual nifedipine in patients with hypertensive emergencies?
p-value: p=<0.001
Sublingual captopril provides rapid and sustained blood pressure reduction without the side effects associated with sublingual nifedipine in hypertensive emergencies.
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May support sublingual captopril for fewer side effects in hypertensive emergencies; Level 3 cohort data leaves open randomized confirmation.
Ceyhan et al. (1990) studied Hypertensive emergencies (n=52). Sublingual captopril vs. Sublingual nifedipine (10-mg) was evaluated on Hypotensive effect (p=<0.001). Sublingual captopril and nifedipine both produced a significant hypotensive effect at 5 minutes (P<0.001), but captopril caused no side-effects compared to 6 patients in the nifedipine group.
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