Key result
Sublingual captopril (83% response rate) and nifedipine (90%) were effective for hypertensive emergencies during hemodialysis, though captopril had fewer side effects; prazosin (11%) was ineffective.
Why the study?
Does sublingual captopril, nifedipine, or prazosin reduce blood pressure in patients with hypertensive emergencies during hemodialysis?
Does sublingual captopril, nifedipine, or prazosin reduce blood pressure in patients with hypertensive emergencies during hemodialysis?
Absolute Event Rate: 83% vs 90%
Sublingual captopril is an effective and safer alternative to nifedipine for hypertensive emergencies during hemodialysis, whereas prazosin is ineffective.
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May support sublingual captopril preference in hemodialysis hypertensive emergencies; leaves open confirmation in randomized trials.
Wu et al. (2008) studied Hypertensive emergencies during hemodialysis. Sublingual captopril, nifedipine, and prazosin vs. Active comparators (each drug compared against the others) was evaluated on Response rate. Sublingual captopril (83% response rate) and nifedipine (90%) were effective for hypertensive emergencies during hemodialysis, though captopril had fewer side effects; prazosin (11%) was ineffective.
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