Key result
Ibopamine significantly improved exercise tolerance (by about 70% on average), clinical condition, and NYHA functional class compared with placebo in patients with severe heart failure.
Why the study?
Does ibopamine improve exercise tolerance and clinical condition in patients with severe symptomatic heart failure receiving standard therapy?
RCT
Double-blind
Randomized
Yes
Does ibopamine improve exercise tolerance and clinical condition in patients with severe symptomatic heart failure receiving standard therapy?
Ibopamine added to digitalis and diuretics significantly improves exercise tolerance and clinical parameters in patients with severe symptomatic heart failure.
Supports adding ibopamine to digitalis and diuretics in severe HF; extends evidence for symptomatic gains on exercise tolerance and NYHA class.
This randomized, double-blind, placebo-controlled, multicenter trial compared the effects of treatment with ibopamine with those of placebo in patients with severe heart failure who still showed symptoms although they were receiving standard therapy with digitalis and diuretics. The results showed a significant and sustained improvement in exercise tolerance (+70% about in average), clinical condition, and NYHA functional class and a decrease in cardiothoracic ratio and left ventricular end-systolic wall stress in patients treated with ibopamine, digitalis, and diuretics (group 1) compared with patients treated with digitalis, diuretics, and placebo (group 2).
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Condorelli et al. (1989) conducted an RCT in Severe heart failure. Ibopamine vs. Placebo was evaluated on Exercise tolerance, clinical condition, NYHA functional class, cardiothoracic ratio, and left ventricular end-systolic wall stress. Ibopamine significantly improved exercise tolerance (by about 70% on average), clinical condition, and NYHA functional class compared with placebo in patients with severe heart failure.
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