Key result
Plasma BNP levels were elevated in 53% of female DMD carriers and significantly correlated with left ventricular end-diastolic dimension (r=0.54), suggesting its utility for detecting cardiac dysfunction.
Why the study?
Do plasma BNP levels correlate with cardiac dysfunction in female gene carriers of Duchenne muscular dystrophy?
Observational (n=15)
No
Do plasma BNP levels correlate with cardiac dysfunction in female gene carriers of Duchenne muscular dystrophy?
Effect estimate: r=0.54
p-value: p=<0.05
Plasma BNP levels may serve as a useful biomarker for the early detection of latent cardiac dysfunction in female carriers of Duchenne muscular dystrophy.
No takes yet. Share an insight, caveat, or question.
May flag latent dysfunction in DMD carriers; hypothesis-generating and should not yet change screening practice.
Adachi et al. (1997) conducted an observational in Female gene carriers of Duchenne Muscular Dystrophy (n=15). Duchenne muscular dystrophy carrier status vs. Normal reference values was evaluated on Correlation between plasma BNP level and left ventricular end-diastolic dimension (LVDd) (r=0.54, p=<0.05). Plasma BNP levels were elevated in 53% of female DMD carriers and significantly correlated with left ventricular end-diastolic dimension (r=0.54), suggesting its utility for detecting cardiac dysfunction.
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