Key result
In a patient with subarachnoid hemorrhage and hyponatremia, plasma atrial natriuretic peptide remained elevated (122 pg/ml) during both the early SIADH phase and the later cerebral salt wasting phase.
Case Report (n=1)
Elevated plasma ANP may contribute to the pathophysiology of increased natriuresis in both SIADH and cerebral salt wasting following subarachnoid hemorrhage.
The authors describe a case of subarachnoid hemorrhage with hyponatremia accompanied by elevation of plasma atrial natriuretic peptide (ANP). The early phase of hyponatremia was classified as the syndrome of inappropriate secretion of antidiuretic hormone (ADH) due to subarachnoid hemorrhage. However, in the later phase, hyponatremia and natriuresis were accompanied by suppression of ADH while plasma ANP remained elevated. The patient was effectively treated with demeclocycline and hypertonic saline. The significance of ANP in the pathophysiology of increased natriuresis is discussed.
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Yamamoto et al. (1989) conducted a case report in Subarachnoid hemorrhage with hyponatremia (n=1). Elevated plasma atrial natriuretic peptide (ANP) was evaluated on Plasma ANP and ADH levels during hyponatremia. In a patient with subarachnoid hemorrhage and hyponatremia, plasma atrial natriuretic peptide remained elevated (122 pg/ml) during both the early SIADH phase and the later cerebral salt wasting phase.
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